diff --git a/CHANGELOG.md b/CHANGELOG.md
index 8fafc87bdb..3432f396cf 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -4,6 +4,7 @@
 ENHANCEMENTS:
 * Specify default_outbound_access_enabled = false setting for all subnets ([#4757](https://github.com/microsoft/AzureTRE/pull/4757))
 * Pin all GitHub Actions workflow steps to full commit SHAs to prevent supply chain attacks plus update to latest releases ([#4886](https://github.com/microsoft/AzureTRE/pull/4886))
+* Configure airlock review VMs to use Nexus proxy for pip and conda package management ([#4009](https://github.com/microsoft/AzureTRE/issues/4009))
 
 ## (0.28.0) (March 2, 2026)
 **BREAKING CHANGES**
diff --git a/templates/workspace_services/guacamole/user_resources/guacamole-azure-export-reviewvm/porter.yaml b/templates/workspace_services/guacamole/user_resources/guacamole-azure-export-reviewvm/porter.yaml
index b8fdcf7f0e..2c465b3ce9 100644
--- a/templates/workspace_services/guacamole/user_resources/guacamole-azure-export-reviewvm/porter.yaml
+++ b/templates/workspace_services/guacamole/user_resources/guacamole-azure-export-reviewvm/porter.yaml
@@ -1,7 +1,7 @@
 ---
 schemaVersion: 1.0.0
 name: tre-service-guacamole-export-reviewvm
-version: 0.3.5
+version: 0.4.0
 description: "An Azure TRE User Resource Template for reviewing Airlock export requests"
 dockerfile: Dockerfile.tmpl
 registry: azuretre
diff --git a/templates/workspace_services/guacamole/user_resources/guacamole-azure-export-reviewvm/terraform/data.tf b/templates/workspace_services/guacamole/user_resources/guacamole-azure-export-reviewvm/terraform/data.tf
index 5379f1a599..cd5998fffd 100644
--- a/templates/workspace_services/guacamole/user_resources/guacamole-azure-export-reviewvm/terraform/data.tf
+++ b/templates/workspace_services/guacamole/user_resources/guacamole-azure-export-reviewvm/terraform/data.tf
@@ -2,6 +2,11 @@ data "azurerm_resource_group" "ws" {
   name = "rg-${var.tre_id}-ws-${local.short_workspace_id}"
 }
 
+data "azurerm_resource_group" "core" {
+  provider = azurerm.core
+  name     = "rg-${var.tre_id}"
+}
+
 data "azurerm_virtual_network" "ws" {
   name                = "vnet-${var.tre_id}-ws-${local.short_workspace_id}"
   resource_group_name = data.azurerm_resource_group.ws.name
@@ -29,6 +34,12 @@ data "azurerm_linux_web_app" "guacamole" {
   resource_group_name = data.azurerm_resource_group.ws.name
 }
 
+data "azurerm_public_ip" "app_gateway_ip" {
+  provider            = azurerm.core
+  name                = "pip-agw-${var.tre_id}"
+  resource_group_name = data.azurerm_resource_group.core.name
+}
+
 data "azurerm_private_endpoint_connection" "airlock_export_inprogress_pe" {
   name                = "pe-sa-export-ip-blob-${local.short_workspace_id}"
   resource_group_name = data.azurerm_resource_group.ws.name
diff --git a/templates/workspace_services/guacamole/user_resources/guacamole-azure-export-reviewvm/terraform/download_review_data.ps1 b/templates/workspace_services/guacamole/user_resources/guacamole-azure-export-reviewvm/terraform/download_review_data.ps1
index 76877d94e5..14fd1f93de 100644
--- a/templates/workspace_services/guacamole/user_resources/guacamole-azure-export-reviewvm/terraform/download_review_data.ps1
+++ b/templates/workspace_services/guacamole/user_resources/guacamole-azure-export-reviewvm/terraform/download_review_data.ps1
@@ -1,3 +1,35 @@
+$ErrorActionPreference = "Stop"
+
+# Configure pip to use Nexus proxy
+$PipConfigFolderPath = "C:\ProgramData\pip\"
+If(!(Test-Path $PipConfigFolderPath))
+{
+  New-Item -ItemType Directory -Force -Path $PipConfigFolderPath
+}
+
+$PipConfigFilePath = $PipConfigFolderPath + "pip.ini"
+
+$ConfigBody = @"
+[global]
+index = ${nexus_proxy_url}/repository/pypi/pypi
+index-url = ${nexus_proxy_url}/repository/pypi/simple
+trusted-host = ${nexus_proxy_url}
+"@
+
+# We need to write the ini file in UTF8 (No BOM) as pip won't understand Powershell's default encoding (unicode)
+$Utf8NoBomEncoding = New-Object System.Text.UTF8Encoding $False
+[System.IO.File]::WriteAllLines($PipConfigFilePath, $ConfigBody, $Utf8NoBomEncoding)
+
+### Anaconda Config
+if( ${CondaConfig} -eq 1 )
+{
+  conda config --add channels ${nexus_proxy_url}/repository/conda-mirror/main/  --system
+  conda config --add channels ${nexus_proxy_url}/repository/conda-repo/main/  --system
+  conda config --remove channels defaults --system
+  conda config --set channel_alias ${nexus_proxy_url}/repository/conda-mirror/  --system
+}
+
+# Download review data
 $DownloadPath = $env:Public + "\Desktop\ReviewData"
 mkdir $DownloadPath
 az storage blob download-batch -d $DownloadPath -s '"${airlock_request_sas_url}"'
diff --git a/templates/workspace_services/guacamole/user_resources/guacamole-azure-export-reviewvm/terraform/locals.tf b/templates/workspace_services/guacamole/user_resources/guacamole-azure-export-reviewvm/terraform/locals.tf
index 33784b6275..2af4ee1aa8 100644
--- a/templates/workspace_services/guacamole/user_resources/guacamole-azure-export-reviewvm/terraform/locals.tf
+++ b/templates/workspace_services/guacamole/user_resources/guacamole-azure-export-reviewvm/terraform/locals.tf
@@ -27,6 +27,8 @@ locals {
   secure_boot_enabled        = lookup(local.selected_image, "secure_boot_enabled", false)
   vtpm_enabled               = lookup(local.selected_image, "vtpm_enabled", false)
 
+  nexus_proxy_url = "https://nexus-${data.azurerm_public_ip.app_gateway_ip.fqdn}"
+
   cmk_name                 = "tre-encryption-${local.workspace_resource_name_suffix}"
   encryption_identity_name = "id-encryption-${var.tre_id}-${local.short_workspace_id}"
 }
diff --git a/templates/workspace_services/guacamole/user_resources/guacamole-azure-export-reviewvm/terraform/main.tf b/templates/workspace_services/guacamole/user_resources/guacamole-azure-export-reviewvm/terraform/main.tf
index 710c099764..fa9780671c 100644
--- a/templates/workspace_services/guacamole/user_resources/guacamole-azure-export-reviewvm/terraform/main.tf
+++ b/templates/workspace_services/guacamole/user_resources/guacamole-azure-export-reviewvm/terraform/main.tf
@@ -2,8 +2,9 @@
 terraform {
   required_providers {
     azurerm = {
-      source  = "hashicorp/azurerm"
-      version = "= 3.117.0"
+      source                = "hashicorp/azurerm"
+      version               = "= 3.117.0"
+      configuration_aliases = [azurerm.core]
     }
     random = {
       source  = "hashicorp/random"
@@ -43,3 +44,9 @@ provider "azurerm" {
   }
   storage_use_azuread = true
 }
+
+provider "azurerm" {
+  alias = "core"
+  features {
+  }
+}
diff --git a/templates/workspace_services/guacamole/user_resources/guacamole-azure-export-reviewvm/terraform/windowsvm.tf b/templates/workspace_services/guacamole/user_resources/guacamole-azure-export-reviewvm/terraform/windowsvm.tf
index 78ef0b044b..9469f4c8e6 100644
--- a/templates/workspace_services/guacamole/user_resources/guacamole-azure-export-reviewvm/terraform/windowsvm.tf
+++ b/templates/workspace_services/guacamole/user_resources/guacamole-azure-export-reviewvm/terraform/windowsvm.tf
@@ -214,6 +214,8 @@ resource "azurerm_key_vault_secret" "windowsvm_password" {
 data "template_file" "download_review_data_script" {
   template = file("${path.module}/download_review_data.ps1")
   vars = {
+    nexus_proxy_url         = local.nexus_proxy_url
+    CondaConfig             = local.selected_image.conda_config ? 1 : 0
     airlock_request_sas_url = var.airlock_request_sas_url
   }
 }
diff --git a/templates/workspace_services/guacamole/user_resources/guacamole-azure-import-reviewvm/porter.yaml b/templates/workspace_services/guacamole/user_resources/guacamole-azure-import-reviewvm/porter.yaml
index 685da7e5a3..603c6d3b20 100644
--- a/templates/workspace_services/guacamole/user_resources/guacamole-azure-import-reviewvm/porter.yaml
+++ b/templates/workspace_services/guacamole/user_resources/guacamole-azure-import-reviewvm/porter.yaml
@@ -1,7 +1,7 @@
 ---
 schemaVersion: 1.0.0
 name: tre-service-guacamole-import-reviewvm
-version: 0.4.4
+version: 0.5.0
 description: "An Azure TRE User Resource Template for reviewing Airlock import requests"
 dockerfile: Dockerfile.tmpl
 registry: azuretre
diff --git a/templates/workspace_services/guacamole/user_resources/guacamole-azure-import-reviewvm/terraform/data.tf b/templates/workspace_services/guacamole/user_resources/guacamole-azure-import-reviewvm/terraform/data.tf
index d3ce0f2eb3..4db7894169 100644
--- a/templates/workspace_services/guacamole/user_resources/guacamole-azure-import-reviewvm/terraform/data.tf
+++ b/templates/workspace_services/guacamole/user_resources/guacamole-azure-import-reviewvm/terraform/data.tf
@@ -2,6 +2,11 @@ data "azurerm_resource_group" "ws" {
   name = "rg-${var.tre_id}-ws-${local.short_workspace_id}"
 }
 
+data "azurerm_resource_group" "core" {
+  provider = azurerm.core
+  name     = "rg-${var.tre_id}"
+}
+
 data "azurerm_virtual_network" "ws" {
   name                = "vnet-${var.tre_id}-ws-${local.short_workspace_id}"
   resource_group_name = data.azurerm_resource_group.ws.name
@@ -23,6 +28,12 @@ data "azurerm_linux_web_app" "guacamole" {
   resource_group_name = data.azurerm_resource_group.ws.name
 }
 
+data "azurerm_public_ip" "app_gateway_ip" {
+  provider            = azurerm.core
+  name                = "pip-agw-${var.tre_id}"
+  resource_group_name = data.azurerm_resource_group.core.name
+}
+
 data "azurerm_key_vault_key" "ws_encryption_key" {
   count        = var.enable_cmk_encryption ? 1 : 0
   name         = local.cmk_name
diff --git a/templates/workspace_services/guacamole/user_resources/guacamole-azure-import-reviewvm/terraform/download_review_data.ps1 b/templates/workspace_services/guacamole/user_resources/guacamole-azure-import-reviewvm/terraform/download_review_data.ps1
index 76877d94e5..14fd1f93de 100644
--- a/templates/workspace_services/guacamole/user_resources/guacamole-azure-import-reviewvm/terraform/download_review_data.ps1
+++ b/templates/workspace_services/guacamole/user_resources/guacamole-azure-import-reviewvm/terraform/download_review_data.ps1
@@ -1,3 +1,35 @@
+$ErrorActionPreference = "Stop"
+
+# Configure pip to use Nexus proxy
+$PipConfigFolderPath = "C:\ProgramData\pip\"
+If(!(Test-Path $PipConfigFolderPath))
+{
+  New-Item -ItemType Directory -Force -Path $PipConfigFolderPath
+}
+
+$PipConfigFilePath = $PipConfigFolderPath + "pip.ini"
+
+$ConfigBody = @"
+[global]
+index = ${nexus_proxy_url}/repository/pypi/pypi
+index-url = ${nexus_proxy_url}/repository/pypi/simple
+trusted-host = ${nexus_proxy_url}
+"@
+
+# We need to write the ini file in UTF8 (No BOM) as pip won't understand Powershell's default encoding (unicode)
+$Utf8NoBomEncoding = New-Object System.Text.UTF8Encoding $False
+[System.IO.File]::WriteAllLines($PipConfigFilePath, $ConfigBody, $Utf8NoBomEncoding)
+
+### Anaconda Config
+if( ${CondaConfig} -eq 1 )
+{
+  conda config --add channels ${nexus_proxy_url}/repository/conda-mirror/main/  --system
+  conda config --add channels ${nexus_proxy_url}/repository/conda-repo/main/  --system
+  conda config --remove channels defaults --system
+  conda config --set channel_alias ${nexus_proxy_url}/repository/conda-mirror/  --system
+}
+
+# Download review data
 $DownloadPath = $env:Public + "\Desktop\ReviewData"
 mkdir $DownloadPath
 az storage blob download-batch -d $DownloadPath -s '"${airlock_request_sas_url}"'
diff --git a/templates/workspace_services/guacamole/user_resources/guacamole-azure-import-reviewvm/terraform/locals.tf b/templates/workspace_services/guacamole/user_resources/guacamole-azure-import-reviewvm/terraform/locals.tf
index 33784b6275..2af4ee1aa8 100644
--- a/templates/workspace_services/guacamole/user_resources/guacamole-azure-import-reviewvm/terraform/locals.tf
+++ b/templates/workspace_services/guacamole/user_resources/guacamole-azure-import-reviewvm/terraform/locals.tf
@@ -27,6 +27,8 @@ locals {
   secure_boot_enabled        = lookup(local.selected_image, "secure_boot_enabled", false)
   vtpm_enabled               = lookup(local.selected_image, "vtpm_enabled", false)
 
+  nexus_proxy_url = "https://nexus-${data.azurerm_public_ip.app_gateway_ip.fqdn}"
+
   cmk_name                 = "tre-encryption-${local.workspace_resource_name_suffix}"
   encryption_identity_name = "id-encryption-${var.tre_id}-${local.short_workspace_id}"
 }
diff --git a/templates/workspace_services/guacamole/user_resources/guacamole-azure-import-reviewvm/terraform/main.tf b/templates/workspace_services/guacamole/user_resources/guacamole-azure-import-reviewvm/terraform/main.tf
index 710c099764..fa9780671c 100644
--- a/templates/workspace_services/guacamole/user_resources/guacamole-azure-import-reviewvm/terraform/main.tf
+++ b/templates/workspace_services/guacamole/user_resources/guacamole-azure-import-reviewvm/terraform/main.tf
@@ -2,8 +2,9 @@
 terraform {
   required_providers {
     azurerm = {
-      source  = "hashicorp/azurerm"
-      version = "= 3.117.0"
+      source                = "hashicorp/azurerm"
+      version               = "= 3.117.0"
+      configuration_aliases = [azurerm.core]
     }
     random = {
       source  = "hashicorp/random"
@@ -43,3 +44,9 @@ provider "azurerm" {
   }
   storage_use_azuread = true
 }
+
+provider "azurerm" {
+  alias = "core"
+  features {
+  }
+}
diff --git a/templates/workspace_services/guacamole/user_resources/guacamole-azure-import-reviewvm/terraform/windowsvm.tf b/templates/workspace_services/guacamole/user_resources/guacamole-azure-import-reviewvm/terraform/windowsvm.tf
index 6d6fc53198..7361f4b219 100644
--- a/templates/workspace_services/guacamole/user_resources/guacamole-azure-import-reviewvm/terraform/windowsvm.tf
+++ b/templates/workspace_services/guacamole/user_resources/guacamole-azure-import-reviewvm/terraform/windowsvm.tf
@@ -135,6 +135,8 @@ resource "azurerm_key_vault_secret" "windowsvm_password" {
 data "template_file" "download_review_data_script" {
   template = file("${path.module}/download_review_data.ps1")
   vars = {
+    nexus_proxy_url         = local.nexus_proxy_url
+    CondaConfig             = local.selected_image.conda_config ? 1 : 0
     airlock_request_sas_url = var.airlock_request_sas_url
   }
 }